Digitalis glycosides

  • 348 Pages
  • 1.56 MB
  • English

Grune & Stratton , Orlando
Cardiac glycosides., Digitalis (Drug), Digitalis Glycos
Other titlesProgress in cardiovascular diseases.
Statementedited by Thomas Woodward Smith.
ContributionsSmith, Thomas Woodward, 1936-
LC ClassificationsRM349 .D54 1986
The Physical Object
Paginationxii, 348 p. :
ID Numbers
Open LibraryOL2536729M
ISBN 100808917315
LC Control Number85017577

Digitalis and its derivatives such as digoxin and digitoxin are cardiac glycosides used typically in the therapy of congestive heart failure and atrial fibrillation.

The cardiac glycosides have not been linked to serum enzyme elevations during therapy or with instances of clinically apparent liver injury. O.H. Drummer, in Encyclopedia of Forensic and Legal Medicine (Second Edition), Digitalis Glycosides. Digitalis glycoside digoxin and digitoxin are potent cardiotonics found in Digitalis spp.

(foxglove). Digoxin is available in tablet form and is prescribed to Digitalis glycosides book with congestive heart failure and atrial fibrillation (Beyer et al., b; Bandara et al., ).

Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides.

Digitalis glycosides are a major cause of poisoning in children {01}. The tolerance of newborn infants to digitalis glycosides is variable, {01} since their renal clearance of the medication is reduced.

Premature and immature infants are especially sensitive {01}. The technique of DCCC has seen rapid expansion over the past few years. It was used to isolate three new glycosides from digitalis lanata using the solvent systems CHCl 3-MeOH-H 2 O () and CH 2 Cl 2-MeOH-H 2 O ().

Four strophanthidin glycosides, out of a total of eight isolated compounds, were separated from one another by DCCC.

Details Digitalis glycosides EPUB

1 Glycosides: Enzymatic and hydrolysis reactions of glycosides, mechanism of action, SAR, therapeutic uses and toxicity of glycosides. Cardiac glycosides of digitalis. Correction of arrhythmias resulting from digitalis toxicitymaybe attemptedwith lidocaine, procainamide, quinidine, propranolol, or phenytoin.

(Digibind), which binds to the digitalis glycoside molecule in the bloodandisexcretedbythekidneys. PotentialNursingDiagnoses Decreasedcardiacoutput(Indications). Later, inthe indication and the toxicity of digitalis were reported in his book, "An account of the Foxglove and some of its medical uses with practical remarks on dropsy, and other diseases".

In Denmark, the leaves of Digitalis purpurea or Digitalis lanata were tested for cardiac glycoside activity. Digitalis Glycoside. Digitalis glycosides can be defined as allosteric inhibitors of Na+- K+-ATPase, a protein cation pump, which uses the energy derived from the hydrolysis of ATP for active transport of potassium ions inside, and sodium ions outside cells (where K+:Na+ is as ).

The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, ; ARONSON, ; PERRIER et ai., ). Research on glycoside kinetics has progressed at a Digitalis glycosides book pace, requiring continuing reevaluation Price: $   There are also other commercial uses of Digitalis lanata other than heart diseases.

For example, in South America, the powdered leaves of Digitalis lanata are used to relieve asthma, as sedatives and diuretics.

Description Digitalis glycosides PDF

In India, it is also used as an ointment that includes digitalis glycosides and is used to treat wounds and burns. Contraindications. Abstract. Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified its use in his classic monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea) in However, a controversy has arisen in the past two decades about whether the risks of digitalis preparations outweigh their.

Digitalis Glycosides Accession Number DBCAT Description. Glycosides from plants of the genus DIGITALIS.

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Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but. Be alert for signs of digitalis toxicity. In adults and older children, the first signs of toxicity usually include abdominal pain, anorexia, nausea, vomiting, visual disturbances, bradycardia, and other arrhythmias.

In infants and small children, the first symptoms. Lugt, C. and Noordhoek-Ananias, L. Quantitative fluorimetric determination of the main cardiac glycosides in Digitalis purpurea leaves. Planta Med ;25(3) View abstract.

Digitalis glycosides. [Thomas Woodward Smith;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book, Internet Resource: All Authors / Contributors: Thomas Woodward Smith.

Find more information about: ISBN: OCLC Number. In spite of old vintage and years of clinical use, digitalis remains an interesting therapeutic agent, to clinicians as well as to the pharmacologist, the biochemist, and colleagues in other diciplines of theoretic medicine.

When a drug, however, has so many attractive facets, it. Digitalis is made from the dried leaves of Digitalis purpurea (common foxglove) plants.

It is a type of cardiac glycoside. Definition (CSP) extract from genus of toxic herbaceous Eurasian plants of the Scrophulaceae which yield cardiotonic digitalis glycosides; most useful species are Digitalis lanata and D.

purpurea. Concepts. The book discusses the use of interfering compounds and artifacts in the identification of drugs in autopsy material; paper and thin layer chromatographic techniques for separation and identification of barbiturates and related hypnotics; and the forensic chemical detection of digitalis glycosides.

The medical use of digitalis was popularized by a British physician, William Withering, whose book, An Account of the Foxglove, was first published in Withering's book contained as the frontispiece a drawing of the foxglove, or Digitalis purpurea, which has wide leaves with serrated edges and tall spikes bearing elongated bell-like.

Digitalis is also the name of a group of drugs (digitalis glycosides) derived from the plant. This is a classic example of an active ingredient formerly used by folklorists and herbalists, now having being identified, purified and used in mainstream medicine. Herbalists have largely abandoned its use because of its narrow therapeutic index and Family: Scrophulariaceae.

Type of the glycosidic linkage: a- glycosides b- glycosides Botanical source: Digitalis glycosides Senna glycosides. Therapeutic use: Analgesic glycosides.

Purgative glycosides. Cardiac glycosides. Digoxin is a cardiac glycoside isolated from plants of the genus Digitalis. The use of preparations of cardiac glycoside (synonyms: digitalis, cardiac steroids) dates back towhen William Withering published his monograph “An account of the foxglove and some of its medical uses” (Withering, ; Albrecht & Geiss, ).

Isolated digoxin has been used since. About Digitalis Glycoside Toxicity: Digitalis glycosides are used to treat heart failure and certain irregular heart beats.

Toxicity can occur when someone accidentally takes more than the recommended amount. Drugs Used to Treat Digitalis Glycoside Toxicity. The following list of medications are in some way related to, or used in the treatment. Digitalis lanata (often called woolly foxglove or Grecian foxglove) is a species of gets its name due to the texture of the leaves.

Digitalis lanata, like some other foxglove species, is toxic in all parts of the ms of digitalis poisoning include nausea, vomiting, severe headache, dilated pupils, problems with eyesight, and convulsions at the worst level of toxicity.

A listing of average digitalis glycoside dosages is provided in formularies for dogs and cats (Tables and ). The dosage regimens published for dogs have used both a mg/kg and mg/m 2 dosing schedule, the latter based on body surface area.

absorption acid activity administration adults agents aminoglycoside amitriptyline antiarrhythmic antibiotic anticonvulsant Antiepileptic Drugs antimicrobial arrhythmias assay asthma atrial bioavailability blood carbamazepine cardiac chloramphenicol chromatography clearance Clin clinical concen concentrations in plasma concentrations in serum.

The foxglove, Digitalis purpurea, contains digoxin, a cardiac plant was used on heart conditions long before the Cardiac Glycoside".Texas A&M University.

Retrieved 26 February The man credited with the introduction of digitalis into The cardiac glycosides are powerful drugs from medicinal plants including foxglove and lily of the valley. Digitalis glycosides are a group of chemically related compounds isolated primarily from plant sources, such as the purple and white foxglove plants (Digitalis purpurea and Digitalis lanata).

Digoxin (generic, Lanoxicaps, Lanoxin ®) is the only form of digitalis glycoside available for clinical use in the USA. Digitalis. (1/) Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea).

Digitalis lanata is an evergreen Biennial/Perennial growing to m (2ft) by m (1ft in). It is in leaf all year, in flower from June to July, and the seeds ripen in September. The species is hermaphrodite (has both male and female organs) and is pollinated by Bees.

Suitable for: light (sandy), medium (loamy) and heavy (clay) soils.The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar and an R group. The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity.

Cardiac glycosides also vary in the groups attached at either .Digoxin should also be used with caution in patients with severe pulmonary disease, acute cor pulmonale, hypoxemia, hypothyroidism or myxedema, severe heart failure, amyloid cardiomyopathy, restrictive cardiomyopathy, or an otherwise damaged myocardium because the myocardium is more sensitive to the effects of digoxin, increasing the risk of.